What is IUI?
Intrauterine insemination (IUI) is a simpler and less invasive, but also less efficient/effective fertility treatment than IVF. It may represent an entirely reasonable initial approach to treatment, but in some cases proceeding directly to IVF may be best. Many factors influence treatment-related decisions, and this will be a key point of focus during your discussions with your provider. Per-cycle and cumulative chance of success over a few cycles is patient-specific and will also be clearly discussed. In most cases, the per-cycle chance of success with IVF far exceeds the per-cycle chance of success associated with IUI-based treatment.
An IUI is a procedure in which processed sperm is placed directly into the uterus at the time of ovulation through the cervix via a small catheter. The sperm can either be from a partner or a sperm donor via a sperm bank and processing (washing/counting/optimizing) takes place at PREG on the day of the procedure.
IUI-based treatment cycles may be coordinated with a natural cycle, but in most cases the procedure is performed following pretreatment with some type of fertility medication(s). The cycle is monitored with ultrasound to ensure optimal timing for IUI, and the IUI procedure, itself, is quick and painless.
When Is an IUI Performed?
IUI may be indicated in the setting of unexplained infertility, when sperm production is not optimal, when donor sperm utilization is necessary, or in other settings which can be discussed with your provider.
Timing of the IUI procedure, itself, is guided by ultrasound monitoring of the cycle and final coordination may be based on either detection of a positive urine-based ovulation predictor kit (OPK) or administration of an injection hCG, commonly known as a trigger injection.
If OPK-based timing is the plan, IUI is typically performed the day following a positive test. When a trigger injection is to be utilized, IUI is typically performed 24-36 hours following administration. If a male partner is present, daily intercourse is recommended for a few days, starting on the day of IUI.
